Clostridium difficile is the leading cause of healthcare-associated infectious diarrhea in adults, affecting 0.3–2% of hospitalized patients. The epidemiology, pathogenesis, clinical manifestations, risk factors, diagnosis and management of cases of Clostridium difficile–associated diarrhea (CDAD) were the subject of a previous publication. The incidence of CDAD varies widely across and within institutions.
In 2003, a marked increase was observed in the incidence,…