Increased risk of hemangioma after exposure to neonatal phototherapy in infants with predisposing risk factors

AIM: To determine the relationship between neonatal phototherapy and future risk of clinically significant hemangioma. METHODS: We analyzed a cohort of 678,879 infants born after 34 weeks gestation comprising 3,975,242 person-years of follow-up over 11 years (2006-2016). The exposure was phototherapy the first 28 days of life. The outcome was hemangioma that required in-hospital treatment during follow-up. We estimated hazard ratios (HR) and 95% confidence intervals (CI) for the association of phototherapy with risk of hemangioma, accounting for preterm birth, low birth weight, and congenital anomalies. RESULTS: The incidence of hemangioma was greater in neonates who received phototherapy than in untreated infants, but there was no association in adjusted models (HR 1.19, 95% CI 0.89-1.58). Risk of hemangioma was elevated in infants who received phototherapy and were born late preterm (HR 2.35, 95% CI 1.51-3.64), with low birth weight (HR 1.91, 95% CI 1.12-3.24), or with anomalies (HR 5.09, 95% CI 3.42-7.58). Without phototherapy, these three risk factors were more weakly associated with hemangioma. CONCLUSION: Neonatal phototherapy in infants with predisposing risk factors may increase the chance of hemangioma, but confirmation in further studies is needed. This article is protected by copyright. All rights reserved.
Auteurs (Zotero)
Auger, Nathalie; Ayoub, Aimina; Lo, Ernest; Luu, Thuy Mai
Date de publication (Zotero)
janvier, 2019